A simple method for predicting transmembrane α helices with better accuracy
نویسندگان
چکیده
منابع مشابه
MemBrain: Improving the Accuracy of Predicting Transmembrane Helices
Prediction of transmembrane helices (TMH) in alpha helical membrane proteins provides valuable information about the protein topology when the high resolution structures are not available. Many predictors have been developed based on either amino acid hydrophobicity scale or pure statistical approaches. While these predictors perform reasonably well in identifying the number of TMHs in a protei...
متن کاملTOPTMH: Topology Predictor for Transmembrane α-Helices
Alpha-helical transmembrane proteins mediate many key biological processes and represent 20–30% of all genes in many organisms. Due to the difficulties in experimentally determining their high-resolution 3D structure, computational methods that predict their topology (transmembrane helical segments and their orientation) are essential in advancing the understanding of membrane proteins’ structu...
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We describe a neural network system that predicts the locations of transmembrane helices in integral membrane proteins. By using evolutionary information as input to the network system, the method significantly improved on a previously published neural network prediction method that had been based on single sequence information. The input data were derived from multiple alignments for each posi...
متن کاملA novel, non-statistical method for predicting breaks in transmembrane helices.
We have developed a novel, non-statistical procedure for predicting possible breaks in transmembrane helices based on energy calculations. The procedure consists of stepwise elongation of the 'core' helical fragment determined by consensus results of several available prediction procedures. At each step, we calculate the conformational energies corresponding to the regular 'frozen' helical conf...
متن کاملA simple statistical method for discriminating outer membrane proteins with better accuracy
MOTIVATION Discriminating outer membrane proteins from other folding types of globular and membrane proteins is an important task both for identifying outer membrane proteins from genomic sequences and for the successful prediction of their secondary and tertiary structures. RESULTS We have systematically analyzed the amino acid composition of globular proteins from different structural class...
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ژورنال
عنوان ژورنال: Protein Engineering, Design and Selection
سال: 1999
ISSN: 1741-0134,1741-0126
DOI: 10.1093/protein/12.7.557